KirBac1.1 changes the dynamic states of the cyclopropane ring. The error is within the size of the symbol in the graph. Insets in ( a), ( b), ( d), and ( e) represent the first derivatives of the DP and rINEPT curves, respectively, with ζ plotting the rate of change of the TG and AT populations, and ξ illustrating the rate of rINEPT signal increase with temperature, which may be related to heterogeneity or second-order phase transitions within the liquid-crystalline lipid phase. The BTL + KB AT peak is indicated as solid magenta squares, and the TG peak is indicated by open magenta circles. In ( d– f), the BTL AT conformer peak intensity is denoted as solid green squares, and TG conformer peak intensities are denoted as open green circles. The ECL + KB AT peak are indicated as solid blue squares, and the TG peak is denoted by open blue circles. In ( a– c), the ECL AT conformer peak intensities are denoted as solid red squares, and TG peak intensity is denoted by open red circles. Integrated peak intensities of AT and TG peaks observed in DP, rINEPT, and CP spectra. If membrane proteins can anneal lipid translational degrees of freedom while preserving internal order, it could offer an explanation to the nature of liquid-ordered protein-lipid organization in vivo.Ĭopyright © 2019. This synergistic effect of KirBac1.1 in bacteriohopanetetrol-rich membranes has implications for bilayer dynamic structure. thailandensis lipid fluidity while preserving internal lipid order. thailandensis liposomes, the bacteriohopanetetrol hopanoid, and potentially ornithine lipids, introduce a similar primary lipid-phase transition and liquid-ordered properties.
Coords channel series#
A solid-state NMR temperature series reveals that KirBac1.1 lowers the primary thermotropic phase transition of Escherichia coli lipid membranes while introducing both fluidity and internal lipid order into the fluid phases. Two-dimensional liquid-state and solid-state NMR experiments were used to assign lipid 1H and 13C chemical shifts as a function of lipid identity and conformational degrees of freedom. KirBac1.1 was reconstituted into vesicles composed of 13C-enriched biological lipids. Here, we show that KirBac1.1 changes the phase properties and dynamics of the surrounding bilayer.
It shares the common inward-rectifier K + channel fold with eukaryotic channels, including conserved lipid-binding pockets. The new GCC technique has many attractive features when applied to bound and unbound states of three-body systems: it is precise, is efficient, and can be extended by introducing a microscopic model of the core.KirBac1.1 is a prokaryotic inward-rectifier K + channel from Burkholderia pseudomallei. Our calculations for A = 6 systems and O 26 show that nucleon-nucleon angular correlations are sensitive to the valence-neutron interaction. Its results for energies, decay widths, and nucleon-nucleon angular correlations are in good agreement with the GSM results.Ĭonclusions: We have demonstrated that a three-body GSM formalism explicitly constructed in the cluster-orbital shell model coordinates provides results similar to those with a GCC framework expressed in Jacobi coordinates, provided that a large configuration space is employed. Results: We show that the GCC method is both accurate and robust. To solve the coupled-channel equations, we use hyperspherical harmonics to describe the angular wave functions while the radial wave functions are expanded in the Berggren ensemble, which includes bound, scattering, and Gamow states. Methods: The GCC formalism is expressed in Jacobi coordinates, so that the center-of-mass motion is automatically eliminated. We benchmarked the complex-energy Gamow shell model (GSM) against the new framework.
Purpose: To describe structure and decays of three-body systems, we developed a Gamow coupled-channel (GCC) approach in Jacobi coordinates by employing the complex-momentum formalism. Theories of such states must take into account configuration mixing effects in the presence of strong coupling to the particle continuum space. Background: Weakly bound and unbound nuclear states appearing around particle thresholds are prototypical open quantum systems.
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